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The constitutively active orphan G-protein-coupled receptor GPR39 protects from cell death by increasing secretion of pigment epithelium-derived growth factor.
Dittmer S, Sahin M, Pantlen A, Saxena A, Toutzaris D, Pina AL, Geerts A, Golz S, Methner A. Dittmer S, et al. J Biol Chem. 2008 Mar 14;283(11):7074-81. doi: 10.1074/jbc.M704323200. Epub 2008 Jan 7. J Biol Chem. 2008. PMID: 18180304 Free article.
GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum response element-mediated transcription. ...In contrast, silencing GPR39 rendered cells more susceptible to cell death. An array analysis of transcripts induced by GPR3
GPR39 is a constitutively active orphan G-protein-coupled receptor capable of increasing serum response element-mediated transcriptio
The NMR structure of human obestatin in membrane-like environments: insights into the structure-bioactivity relationship of obestatin.
Alén BO, Nieto L, Gurriarán-Rodríguez U, Mosteiro CS, Álvarez-Pérez JC, Otero-Alén M, Camiña JP, Gallego R, García-Caballero T, Martín-Pastor M, Casanueva FF, Jiménez-Barbero J, Pazos Y. Alén BO, et al. PLoS One. 2012;7(10):e45434. doi: 10.1371/journal.pone.0045434. Epub 2012 Oct 4. PLoS One. 2012. PMID: 23056203 Free PMC article.